| Topic: |
Religions > Atheism |
| User: |
"Michael Gray" |
| Date: |
04 Feb 2008 07:42:41 PM |
| Object: |
AA: OT: Pregnancy & Caffeine |
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Several studies have linked caffeine to higher rates of miscarriage,
but critics said the results could be skewed by women with healthy
pregnancies reducing their caffeine intake because of morning
sickness.
De-Kun Li at California-based health insurer Kaiser Permanente
interviewed 1063 women early in their pregnancies about their caffeine
consumption, looking at both those who changed their drinking patterns
and those who didn't. All women were followed to 20 weeks of pregnancy
or until miscarriage.
Consumption of 200 milligrams or more of caffeine per day - equivalent
to just over one cup of coffee - was associated with a more than
twofold increase in miscarriage. Caffeinated fizzy drinks, tea and hot
chocolate all showed the same effect (American Journal of Obstetrics
and Gynecology, DOI: 10.1016/j.ajog.2007.10.803).
Li believes that caffeine, which constricts blood vessels, may be
restricting blood flow to the placenta. Alternatively, it may have a
toxic effect on the fetus. He says women should try to forgo all
caffeine during pregnancy. "It's not a big sacrifice."
From issue 2640 of New Scientist magazine, 26 January 2008, page 19
Original "American Journal of Obstetrics & Gynecology" Paper:
<http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9P-4RNS35V-8&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=425dd2c3c08cbc6b789f132f49fc392a>
=
http://tinyurl.com/2mn4xo
Excerpt:
"Results:
An increasing dose of daily caffeine intake during pregnancy was
associated with an increased risk of miscarriage, compared with no
caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95%
confidence interval 0.93 to 2.15) for caffeine intake of less than 200
mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more
mg/day, respectively. Nausea or vomiting during pregnancy did not
materially affect this observed association, nor did the change in
intake pattern of caffeine during pregnancy. In addition, the
magnitude of the association appeared to be stronger among women
without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that
among women with such a history (aHR 0.81, 0.34 to 1.94).
Conclusion:
Our results demonstrated that high doses of caffeine intake during
pregnancy increase the risk of miscarriage, independent of
pregnancy-related symptoms."
.
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| User: "Robibnikoff" |
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| Title: Re: OT: Pregnancy & Caffeine |
05 Feb 2008 04:42:03 AM |
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"Michael Gray" <mikegray@newsguy.com> wrote in message
news:ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com...
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Um, no kidding. I heard this 12 years ago and didn't touch it when I found
out I was pregnant with the witchling. Why is this news now?
--
Robyn
Resident Witchypoo
BAAWA Knight!
#1557
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| User: "Michael Gray" |
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| Title: Re: OT: Pregnancy & Caffeine |
05 Feb 2008 09:40:55 PM |
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On Tue, 5 Feb 2008 05:42:03 -0500, "Robibnikoff"
<witchypoo@broomstick.com> wrote:
"Michael Gray" <mikegray@newsguy.com> wrote in message
news:ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com...
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Um, no kidding. I heard this 12 years ago and didn't touch it when I found
out I was pregnant with the witchling. Why is this news now?
It was just a guess (or "judgement") at that stage, without clinical
support.
It has finally been shown to be true in effectively run trials.
I guess that the main issue is the very low dose required to exert a
profound effect, vis: no more than one cup a day!
.
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| User: "johac" |
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| Title: Re: OT: Pregnancy & Caffeine |
06 Feb 2008 12:11:24 AM |
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In article <mtaiq395cbu9mo9n0h0erg0o73cii7cji6@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
On Tue, 5 Feb 2008 05:42:03 -0500, "Robibnikoff"
<witchypoo@broomstick.com> wrote:
"Michael Gray" <mikegray@newsguy.com> wrote in message
news:ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com...
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Um, no kidding. I heard this 12 years ago and didn't touch it when I found
out I was pregnant with the witchling. Why is this news now?
It was just a guess (or "judgement") at that stage, without clinical
support.
It has finally been shown to be true in effectively run trials.
I guess that the main issue is the very low dose required to exert a
profound effect, vis: no more than one cup a day!
Has anyone figured out the mechanism?
--
John #1782
.
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| User: "Michael Gray" |
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| Title: Re: OT: Pregnancy & Caffeine |
06 Feb 2008 01:18:33 AM |
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On Tue, 05 Feb 2008 22:11:24 -0800, johac
<jhachmann@remove.sbcglobal.net> wrote:
In article <mtaiq395cbu9mo9n0h0erg0o73cii7cji6@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
On Tue, 5 Feb 2008 05:42:03 -0500, "Robibnikoff"
<witchypoo@broomstick.com> wrote:
"Michael Gray" <mikegray@newsguy.com> wrote in message
news:ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com...
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Um, no kidding. I heard this 12 years ago and didn't touch it when I found
out I was pregnant with the witchling. Why is this news now?
It was just a guess (or "judgement") at that stage, without clinical
support.
It has finally been shown to be true in effectively run trials.
I guess that the main issue is the very low dose required to exert a
profound effect, vis: no more than one cup a day!
Has anyone figured out the mechanism?
Not that I know of.
I have my suspicions, though.
.
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| User: "johac" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
05 Feb 2008 12:45:20 AM |
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In article <ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Several studies have linked caffeine to higher rates of miscarriage,
but critics said the results could be skewed by women with healthy
pregnancies reducing their caffeine intake because of morning
sickness.
De-Kun Li at California-based health insurer Kaiser Permanente
interviewed 1063 women early in their pregnancies about their caffeine
consumption, looking at both those who changed their drinking patterns
and those who didn't. All women were followed to 20 weeks of pregnancy
or until miscarriage.
Consumption of 200 milligrams or more of caffeine per day - equivalent
to just over one cup of coffee - was associated with a more than
twofold increase in miscarriage. Caffeinated fizzy drinks, tea and hot
chocolate all showed the same effect (American Journal of Obstetrics
and Gynecology, DOI: 10.1016/j.ajog.2007.10.803).
Li believes that caffeine, which constricts blood vessels, may be
restricting blood flow to the placenta. Alternatively, it may have a
toxic effect on the fetus. He says women should try to forgo all
caffeine during pregnancy. "It's not a big sacrifice."
From issue 2640 of New Scientist magazine, 26 January 2008, page 19
I wonder. Does anyone know the mechanism for how caffeine affects the
fetus?
Original "American Journal of Obstetrics & Gynecology" Paper:
<http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9P-4RNS35V-8&_use
r=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_ur
lVersion=0&_userid=10&md5=425dd2c3c08cbc6b789f132f49fc392a>
=
http://tinyurl.com/2mn4xo
Excerpt:
"Results:
An increasing dose of daily caffeine intake during pregnancy was
associated with an increased risk of miscarriage, compared with no
caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95%
confidence interval 0.93 to 2.15) for caffeine intake of less than 200
mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more
mg/day, respectively. Nausea or vomiting during pregnancy did not
materially affect this observed association, nor did the change in
intake pattern of caffeine during pregnancy. In addition, the
magnitude of the association appeared to be stronger among women
without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that
among women with such a history (aHR 0.81, 0.34 to 1.94).
Conclusion:
Our results demonstrated that high doses of caffeine intake during
pregnancy increase the risk of miscarriage, independent of
pregnancy-related symptoms."
--
John #1782
.
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| User: "Michael Gray" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
05 Feb 2008 01:03:31 AM |
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On Mon, 04 Feb 2008 22:45:20 -0800, johac
<jhachmann@remove.sbcglobal.net> wrote:
In article <ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Several studies have linked caffeine to higher rates of miscarriage,
but critics said the results could be skewed by women with healthy
pregnancies reducing their caffeine intake because of morning
sickness.
De-Kun Li at California-based health insurer Kaiser Permanente
interviewed 1063 women early in their pregnancies about their caffeine
consumption, looking at both those who changed their drinking patterns
and those who didn't. All women were followed to 20 weeks of pregnancy
or until miscarriage.
Consumption of 200 milligrams or more of caffeine per day - equivalent
to just over one cup of coffee - was associated with a more than
twofold increase in miscarriage. Caffeinated fizzy drinks, tea and hot
chocolate all showed the same effect (American Journal of Obstetrics
and Gynecology, DOI: 10.1016/j.ajog.2007.10.803).
Li believes that caffeine, which constricts blood vessels, may be
restricting blood flow to the placenta. Alternatively, it may have a
toxic effect on the fetus. He says women should try to forgo all
caffeine during pregnancy. "It's not a big sacrifice."
From issue 2640 of New Scientist magazine, 26 January 2008, page 19
I wonder. Does anyone know the mechanism for how caffeine affects the
fetus?
Only those above guesses at this stage.
It may also act on the placenta.
The fact that caffeine is a poison may have something to do with it!
:
.
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| User: "johac" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
06 Feb 2008 12:15:00 AM |
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In article <8e2gq3p66pdsfsmj7mfjibp47i30sp08bs@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
On Mon, 04 Feb 2008 22:45:20 -0800, johac
<jhachmann@remove.sbcglobal.net> wrote:
In article <ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Several studies have linked caffeine to higher rates of miscarriage,
but critics said the results could be skewed by women with healthy
pregnancies reducing their caffeine intake because of morning
sickness.
De-Kun Li at California-based health insurer Kaiser Permanente
interviewed 1063 women early in their pregnancies about their caffeine
consumption, looking at both those who changed their drinking patterns
and those who didn't. All women were followed to 20 weeks of pregnancy
or until miscarriage.
Consumption of 200 milligrams or more of caffeine per day - equivalent
to just over one cup of coffee - was associated with a more than
twofold increase in miscarriage. Caffeinated fizzy drinks, tea and hot
chocolate all showed the same effect (American Journal of Obstetrics
and Gynecology, DOI: 10.1016/j.ajog.2007.10.803).
Li believes that caffeine, which constricts blood vessels, may be
restricting blood flow to the placenta. Alternatively, it may have a
toxic effect on the fetus. He says women should try to forgo all
caffeine during pregnancy. "It's not a big sacrifice."
From issue 2640 of New Scientist magazine, 26 January 2008, page 19
I wonder. Does anyone know the mechanism for how caffeine affects the
fetus?
Only those above guesses at this stage.
It may also act on the placenta.
The fact that caffeine is a poison may have something to do with it!
:
I'm wondering since caffeine is a purine, does it have something to do
with the DNA of the developing fetus?
(I forgot I asked this last night and asked again in response to another
post)
--
John #1782
.
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| User: "Michael Gray" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
06 Feb 2008 01:07:31 AM |
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On Tue, 05 Feb 2008 22:15:00 -0800, johac
<jhachmann@remove.sbcglobal.net> wrote:
In article <8e2gq3p66pdsfsmj7mfjibp47i30sp08bs@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
On Mon, 04 Feb 2008 22:45:20 -0800, johac
<jhachmann@remove.sbcglobal.net> wrote:
In article <ldffq3hgli0o7u7obmht9dp8r93ibjmhva@4ax.com>,
Michael Gray <mikegray@newsguy.com> wrote:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
Several studies have linked caffeine to higher rates of miscarriage,
but critics said the results could be skewed by women with healthy
pregnancies reducing their caffeine intake because of morning
sickness.
De-Kun Li at California-based health insurer Kaiser Permanente
interviewed 1063 women early in their pregnancies about their caffeine
consumption, looking at both those who changed their drinking patterns
and those who didn't. All women were followed to 20 weeks of pregnancy
or until miscarriage.
Consumption of 200 milligrams or more of caffeine per day - equivalent
to just over one cup of coffee - was associated with a more than
twofold increase in miscarriage. Caffeinated fizzy drinks, tea and hot
chocolate all showed the same effect (American Journal of Obstetrics
and Gynecology, DOI: 10.1016/j.ajog.2007.10.803).
Li believes that caffeine, which constricts blood vessels, may be
restricting blood flow to the placenta. Alternatively, it may have a
toxic effect on the fetus. He says women should try to forgo all
caffeine during pregnancy. "It's not a big sacrifice."
From issue 2640 of New Scientist magazine, 26 January 2008, page 19
I wonder. Does anyone know the mechanism for how caffeine affects the
fetus?
Only those above guesses at this stage.
It may also act on the placenta.
The fact that caffeine is a poison may have something to do with it!
:
I'm wondering since caffeine is a purine,
I did not know that.
I learn something new every day! :)
(Do not purines cause, or aggravte, gout? Or am I thinking of another
protein homonym?)
does it have something to do
with the DNA of the developing fetus?
It may well do.
But, as I suggested, it has a direct effect upon the placenta, and I
suspect (from a position of admitted abject ignorance) that this may
have more to do with it.
Perhaps you should consult the authors of the paper?
(I forgot I asked this last night and asked again in response to another
post)
I did not spy that request.
.
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| User: "Mike Ruskai" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
05 Feb 2008 10:54:44 PM |
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On or about Tue, 05 Feb 2008 12:12:41 +1030 did Michael Gray
<mikegray@newsguy.com> dribble thusly:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
No, that study shows that it's correlated with a higher risk of
miscarriage, not that it causes it.
There may well be causation, but you can't determine that from the
analysis done.
It's entirely possible that caffeine consumption is itself merely
correlated with some other cause of increased miscarriage rates. Or
several such causes.
For example, consider that many miscarriages are due to genetic
defects in the embryo (most, in the first trimester). There may be
genes which influence the likelihood that someone will be a coffee
drinker, and those same genes could increase the likelihood of a
miscarriage. I don't consider that very likely, but it's just an
example of the kind of thing that isn't remotely controlled for in the
referenced study.
.
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| User: "Michael Gray" |
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| Title: Re: AA: OT: Pregnancy & Caffeine |
06 Feb 2008 01:10:09 AM |
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On Tue, 05 Feb 2008 23:54:44 -0500, Mike Ruskai
<BUTthannydI@DONTearthlinkLIKE.netSPAM> wrote:
On or about Tue, 05 Feb 2008 12:12:41 +1030 did Michael Gray
<mikegray@newsguy.com> dribble thusly:
Coffee increases miscarriage risk
26 January 2008
"IT'S bad news for tired mothers-to-be. The long-running controversy
about whether drinking coffee increases the chance of miscarriage may
have been laid to rest: it does.
No, that study shows that it's correlated with a higher risk of
miscarriage, not that it causes it.
There may well be causation, but you can't determine that from the
analysis done.
It's entirely possible that caffeine consumption is itself merely
correlated with some other cause of increased miscarriage rates. Or
several such causes.
For example, consider that many miscarriages are due to genetic
defects in the embryo (most, in the first trimester). There may be
genes which influence the likelihood that someone will be a coffee
drinker, and those same genes could increase the likelihood of a
miscarriage. I don't consider that very likely, but it's just an
example of the kind of thing that isn't remotely controlled for in the
referenced study.
You are, of course, technically correct. :)
Corralation is *not* equivalent to causation.
(In either direction)
You may as well resume a 2 pack a day nicotine habit.
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