| Topic: |
Religions > Atheism |
| User: |
"johac" |
| Date: |
03 Oct 2006 06:52:23 AM |
| Object: |
Two U.S. scientists win Nobel for "gene silencing" |
This area has a lots of promise.
---
Two U.S. scientists win Nobel for "gene silencing"
By Sarah Edmonds and Patrick LanninMon Oct 2, 6:25 PM ET
Americans Andrew Fire and Craig Mello won the 2006 Nobel Prize for
medicine on Monday for their discovery of how to switch off genes, a
potential road to new treatments for diseases from AIDS to blindness and
cancer.
Fire, 47, and Mello, 45, are among the youngest in recent history to win
the prize of 10 million Swedish crowns ($1.37 million). Their work,
which was published in 1998, received remarkably swift recognition.
Through experiments with worms, the two showed that a double strand of
ribonucleic acid, or RNA, the genetic messenger of the cell, can
"silence" targeted genes in a process known as RNA interference (RNAi).
RNAi has grown quickly into a hot area of research for pharmaceutical
and biotechnology companies, who see it as a promising way of tackling a
range of conditions.
"Craig's and my work (concerned) why some genes get turned off," Fire
told Reuters.
"We were trying to manipulate them and we found certain things could
turn them off very efficiently ... Knowing the genes doesn't tell you
what they do, so if you start to turn them off you can start to learn
what they do."
The discoveries may lead to methods to stop gene expression in diseases
such as cancer, slowing tumor growth.
"The discovery is already being used in clinical trials for viral
diseases, for eye diseases, for cardiovascular metabolic diseases,"
Bertil Fredholm, a member of the prize-giving Nobel Assembly of
Stockholm's Karolinska Institute, told Reuters.
"But even more importantly, it is being used in every drug industry as a
fundamental research tool," he added, saying RNAi has "invaded"
laboratories worldwide.
Phillip Sharp of the Whitehead Institute for Biomedical Research in
Massachusetts, himself a 1993 Nobel prize winner, has used RNAi to kill
HIV, the virus that causes AIDS.
UNUSUALLY FAST
Nobel prizes are often granted to winning work decades later but
Fredholm said the selection of Mello and Fire was due to the clear
importance of their findings.
"Sometimes it is immediately apparent to the Nobel committee that a
discovery is a really fundamental one," he said.
He cited 1962 Nobel Laureates James Watson and Francis Crick, who won
their prize just nine years after discovering the structure of DNA, the
fundamental building block of life.
Mello, who developed a fascination with the origins of life digging for
dinosaur bones in the western United States with his paleontologist
father, said he had suspected the work might win a prize but not for
another 10 or 20 years.
"It's amazing. It just hasn't sunk in yet," he said from his
Massachusetts home.
Fire earned his Ph.D. in biology in 1983 at the Massachusetts Institute
of Technology and is now a professor of pathology and genetics at
Stanford University School of Medicine. Mello has a Harvard doctorate
and is a professor of molecular medicine at the University of
Massachusetts Medical School.
The Massachusetts school said a number of firms -- Novartis AG,
Bristol-Myers Squibb, Monsanto Co., GlaxoSmithKline and Pfizer -- had
licensed RNAi for their research.
Massachusetts-based Alnylam Pharmaceuticals Inc. has used RNAi to block
a gene involved in cholesterol metabolism, for example, and this week
won a grant from the National Institute of Allergy and Infectious
Diseases to use the technology against H5N1 avian influenza.
Fire, born at Stanford Hospital and raised in Sunnyvale, California,
told a news conference at Stanford University he hoped winning the Nobel
Prize would attract attention to and funding from the National
Institutes of Health for basic research into cell biology by academics,
who must compete for the money with efforts focused on cures for
diseases.
"Tomorrow I go back to the lab," Fire added.
Mello also hoped the prize would attract research money.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
---
http://news.yahoo.com/s/nm/20061002/ts_nm/nobel_medicine_dc;_ylt=Ah9RVeEg
bvmvA0KRGyfY9gdZ.3QA;_ylu=X3oDMTA5aHJvMDdwBHNlYwN5bmNhdA--
or
http://tinyurl.com/g9geo
--
John Hachmann aa #1782
"Those who can make you believe absurdities can make you commit atrocities"
-Voltaire
Contact - Throw a .net over the .com
.
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| User: "Uncle Clover" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
03 Oct 2006 10:45:26 PM |
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<snip>
Play this technology just right, and in no time it will be possible to produce
multiple kinds of lifeforms from a single genome. Take a seed with a single
genetic sequence that contains instructions for five different kinds of
organisms. Make five copies of the seed; Feed each of the five different things
(to shut off different combinations of genes) and - WALLAH! You'll have five
completely different organisms, all from the same seed.
Genetic engineering won't be a matter of splicing and dicing anymore - just add
the genes you want, don't bother removing any of the old stuff. What you don't
need can just be shut off...
Very interesting.... :-)
--
L8r,
Uncle Clover
************************************************
The true mark of a civilized society is that its
citizens know how to hate each other peacefully.
************************************************
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| User: "johac" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
04 Oct 2006 05:14:11 AM |
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In article <lpp5i2p0sl4qpc05meenqcb135civpp9r6@4ax.com>,
Uncle Clover <UncleClover@SpamMeNot.com> wrote:
<snip>
Play this technology just right, and in no time it will be possible to
produce
multiple kinds of lifeforms from a single genome. Take a seed with a single
genetic sequence that contains instructions for five different kinds of
organisms. Make five copies of the seed; Feed each of the five different
things
(to shut off different combinations of genes) and - WALLAH! You'll have five
completely different organisms, all from the same seed.
Genetic engineering won't be a matter of splicing and dicing anymore - just
add
the genes you want, don't bother removing any of the old stuff. What you
don't
need can just be shut off...
Very interesting.... :-)
The problem is that the RNAi would not be passed along to the progeny of
the altered organism and it would revert to the original. It might be
possible to splice a DNA segment into the genome of the parent organism
that when expressed would produce the RNAi needed. This would require a
bit more work, but it seems doable.
--
John Hachmann aa #1782
"Those who can make you believe absurdities can make you commit atrocities"
-Voltaire
Contact - Throw a .net over the .com
.
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| User: "stoney" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
08 Oct 2006 02:29:51 AM |
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On Tue, 03 Oct 2006 18:45:26 -0400, Uncle Clover
<UncleClover@SpamMeNot.com> wrote in alt.atheism
<snip>
Play this technology just right, and in no time it will be possible to produce
multiple kinds of lifeforms from a single genome. Take a seed with a single
genetic sequence that contains instructions for five different kinds of
organisms. Make five copies of the seed; Feed each of the five different things
(to shut off different combinations of genes) and - WALLAH! You'll have five
completely different organisms, all from the same seed.
Genetic engineering won't be a matter of splicing and dicing anymore - just add
the genes you want, don't bother removing any of the old stuff. What you don't
need can just be shut off...
Very interesting.... :-)
Get rid of superstitious tendencies in one go. :)
--
Fundies and trolls are cordially invited to
shove a wooden cross up their arses and rotate
at a high rate of speed. I trust you'll
be 'blessed' with a plethora of splinters.
.
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| User: "stoney" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
08 Oct 2006 02:28:28 AM |
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On Mon, 02 Oct 2006 23:52:23 -0700, johac <jhachmann@sbcglobal.com>
wrote in alt.atheism
This area has a lots of promise.
---
Two U.S. scientists win Nobel for "gene silencing"
By Sarah Edmonds and Patrick LanninMon Oct 2, 6:25 PM ET
Americans Andrew Fire and Craig Mello won the 2006 Nobel Prize for
medicine on Monday for their discovery of how to switch off genes, a
potential road to new treatments for diseases from AIDS to blindness and
cancer.
Fire, 47, and Mello, 45, are among the youngest in recent history to win
the prize of 10 million Swedish crowns ($1.37 million). Their work,
which was published in 1998, received remarkably swift recognition.
[]
"Tomorrow I go back to the lab," Fire added.
Mello also hoped the prize would attract research money.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
[]
But there's plenty of money to destroy and kill. Bad prioritization.
--
Fundies and trolls are cordially invited to
shove a wooden cross up their arses and rotate
at a high rate of speed. I trust you'll
be 'blessed' with a plethora of splinters.
.
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| User: "johac" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
08 Oct 2006 06:04:09 AM |
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In article <igogi2dqf3p85l6uek57f4o6a3lj1cnf2k@4ax.com>,
stoney <stoney@the.net> wrote:
On Mon, 02 Oct 2006 23:52:23 -0700, johac <jhachmann@sbcglobal.com>
wrote in alt.atheism
This area has a lots of promise.
---
Two U.S. scientists win Nobel for "gene silencing"
By Sarah Edmonds and Patrick LanninMon Oct 2, 6:25 PM ET
Americans Andrew Fire and Craig Mello won the 2006 Nobel Prize for
medicine on Monday for their discovery of how to switch off genes, a
potential road to new treatments for diseases from AIDS to blindness and
cancer.
Fire, 47, and Mello, 45, are among the youngest in recent history to win
the prize of 10 million Swedish crowns ($1.37 million). Their work,
which was published in 1998, received remarkably swift recognition.
[]
"Tomorrow I go back to the lab," Fire added.
Mello also hoped the prize would attract research money.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
[]
But there's plenty of money to destroy and kill. Bad prioritization.
I know. I wonder how many lives could be saved with the money that
Fearful Leader is squandering on his senseless war.
--
John Hachmann aa #1782
"Those who can make you believe absurdities can make you commit atrocities"
-Voltaire
Contact - Throw a .net over the .com
.
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| User: "stoney" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
09 Oct 2006 06:16:21 PM |
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On Sat, 07 Oct 2006 23:04:09 -0700, johac <jhachmann@sbcglobal.com>
wrote in alt.atheism
In article <igogi2dqf3p85l6uek57f4o6a3lj1cnf2k@4ax.com>,
stoney <stoney@the.net> wrote:
On Mon, 02 Oct 2006 23:52:23 -0700, johac <jhachmann@sbcglobal.com>
wrote in alt.atheism
This area has a lots of promise.
---
Two U.S. scientists win Nobel for "gene silencing"
By Sarah Edmonds and Patrick LanninMon Oct 2, 6:25 PM ET
Americans Andrew Fire and Craig Mello won the 2006 Nobel Prize for
medicine on Monday for their discovery of how to switch off genes, a
potential road to new treatments for diseases from AIDS to blindness and
cancer.
Fire, 47, and Mello, 45, are among the youngest in recent history to win
the prize of 10 million Swedish crowns ($1.37 million). Their work,
which was published in 1998, received remarkably swift recognition.
[]
"Tomorrow I go back to the lab," Fire added.
Mello also hoped the prize would attract research money.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
[]
But there's plenty of money to destroy and kill. Bad prioritization.
I know. I wonder how many lives could be saved with the money that
Fearful Leader is squandering on his senseless war.
Mega, not to mention investing in basic research.
--
Fundies and trolls are cordially invited to
shove a wooden cross up their arses and rotate
at a high rate of speed. I trust you'll
be 'blessed' with a plethora of splinters.
.
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| User: "Panama Floyd" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
03 Oct 2006 06:56:38 AM |
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johac wrote:
snip incredibly cool story.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
This, my friends will be the United States' epitaph.
-PF, Atl.
#2015/KoBAAWA!
.
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| User: "Hotel Charlie One" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
03 Oct 2006 01:14:16 PM |
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"Panama Floyd" <googpostlimitsux@hotmail.com> wrote in
news:1159858598.613144.97550@h48g2000cwc.googlegroups.com:
johac wrote:
snip incredibly cool story.
"I'm sad to say we are not spending enough money as a nation on
basic research," he said.
This, my friends will be the United States' epitaph.
-PF, Atl.
#2015/KoBAAWA!
But you really can't blame business because for each new product
created to help 99.9% of the people, there will be 100 lawyers to
bring lawsuits of behalf of the 0.1% damaged.
--
The actions of the disgraceful Clinton and Bush administrations
make it possible for me to say without shame that I deeply regret
the day I put the uniform of my country. The freedoms that I was
willing to protect with my life are being lost. The America of
our founders is dead. All we are waiting for now is rigor mortis.
HotelCharlieOne
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| User: "" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
05 Oct 2006 01:32:30 AM |
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Hotel Charlie One wrote:
"Panama Floyd" <googpostlimitsux@hotmail.com> wrote in
news:1159858598.613144.97550@h48g2000cwc.googlegroups.com:
johac wrote:
snip incredibly cool story.
"I'm sad to say we are not spending enough money as a nation on
basic research," he said.
This, my friends will be the United States' epitaph.
-PF, Atl.
#2015/KoBAAWA!
But you really can't blame business because for each new product
created to help 99.9% of the people, there will be 100 lawyers to
bring lawsuits of behalf of the 0.1% damaged.
That goes back to that old saw about a nation that graduates twice as
many lawyers as it does engineers deserves what it gets.
-Panama Floyd, Atl.
aa#2015, Member Knights of BAAWA!
EAC Martian Commander
Plonked by Kadaitcha Man Sept 06
"..the prayer cloth of one aeon is the doormat of the next."
-Mark Twain
Religious societies are *less* moral than secular ones:
http://moses.creighton.edu/JRS/2005/2005-11.html
.
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| User: "johac" |
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| Title: Re: Two U.S. scientists win Nobel for "gene silencing" |
04 Oct 2006 05:16:54 AM |
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In article <1159858598.613144.97550@h48g2000cwc.googlegroups.com>,
"Panama Floyd" <googpostlimitsux@hotmail.com> wrote:
johac wrote:
snip incredibly cool story.
"I'm sad to say we are not spending enough money as a nation on basic
research," he said.
This, my friends will be the United States' epitaph.
Their work was published in 1998. I wonder how many American Nobel
laureates we will see in the future?
--
John Hachmann aa #1782
"Those who can make you believe absurdities can make you commit atrocities"
-Voltaire
Contact - Throw a .net over the .com
.
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