Nom de Plume - and thanks to others



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Topic: Sociology > Depression
User: "Allure30"
Date: 23 Mar 2005 11:02:16 AM
Object: Nom de Plume - and thanks to others
Hi,
First, thank you for answering me pertinent answers :)
Nom de Plume, are you a psychiatrist? psychologist? Where are you
from? Are you ill or a doctor?
Thanks for answering me.
I may look at Depakote, maybe or Anafranil, since I am depressed and
DP unit at London has showed good results with this med. But not SSRI
for me....
I will look at other answers too!
Allure xxx
.

User: "Nom dePlume nomdeplume1000-at-yahoo.com"

Title: Re: Nom de Plume - and thanks to others 23 Mar 2005 10:23:46 PM
"Allure30" <karine3479@yahoo.ca> wrote in message
news:fdf8dd65.0503230902.2c4cb97c@posting.google.com...

Hi,

First, thank you for answering me pertinent answers :)

Nom de Plume, are you a psychiatrist? psychologist? Where are you
from? Are you ill or a doctor?

Am I "ill or a doctor?" What a choice!
I'm a physicist who makes his living, nowadays, in software
engineering. I've had some serious health problems, including
depression, and learned a fair amount about mood disorders and
medications in the process of finding useful treatment for my own
depression. I like to share what I've learned with other people, and
learn more, which is why I hang out in places like this, and maintain
my Web site.

Thanks for answering me.

You're welcome. I wish you luck. Do let us know how you are doing, OK?

I may look at Depakote, maybe or Anafranil, since I am depressed and
DP unit at London has showed good results with this med. But not

SSRI

for me....

I will look at other answers too!

Allure xxx

--
Nom dePlume, Ph.D
Why, yes, in fact, I am a rocket scientist.
Guide to Medications for Mental Illness:
http://www.geocities.com/nomdeplume1000
=====
.
User: "Nom dePlume nomdeplume1000-at-yahoo.com"

Title: Re: Nom de Plume - and thanks to others 24 Mar 2005 12:40:19 AM
I looked at my post in this newsgroup, where I claimed to have copied
the text from my response to you in the medication newsgroup, and
found I hadn't! I think you must have read it, given your comments,
but I'll put it here again (for real) just to be on the safe side.
===
Hello, Allure. I'm sorry that you are feeling so bad. I'm not
surprised SSRIs made you feel worse. They help many people, they can
also cause emotional flatness, and if you are already feeling numb, I
can see that being a big problem.
Since you're tried all the SSRIs (!) without benefit, I suggest you
try something else. SSRIs, as you know, increase the concentration of
serotonin in the brain. That's fine for some people who are depressed,
but not others. (In my case, for example, increasing serotonin has
only negative effects.) The other major neurotransmitters most often
affected by medications for depression are norepinephrine and
dopamine.
Increasing norepinephrine usually increases energy and ability to
concentrate.
Increasing dopamine primarily increases the ability to feel positive
emotions (joy, happiness, etc.), sensuality, and sexual desire. It
secondarily increases energy, because it is a norepinephrine precursor
(i.e. is converted into norepinephrine).
If your condition is one characterized by a lack of positive feelings
(the condition called "anhedonia"), then I would expect medications
that increase the concentration of, or substitute for, dopamine to be
more appropriate than SSRIs, and I'd be inclined to avoid doing
anything that raises serotonin concentration. Here are some
medications that fits the above criteria:
Wellbutrin: Norepinephrine-dopamine reuptake inhibitor. Increases
concentration of norepinephrine and (less strongly) dopamine. It is a
well-regarded medication, and one of very few standard antidepressants
that does not have a significant serotonergic action.
If Wellbutrin isn't strongly dopaminergic enough, a couple other
possibilities come to mind:
Selegiline: A MAO-B inhibitor. It strongly increases the concentration
of dopamine (and, therefore secondarily, norepinephrine). You have to
be careful to avoid taking certain other medicines with it (such as
cough syrup and decongestants), and some people (not all) need to be
careful about what foods they eat, but it is a very powerful
medication.
Dopamine agonists: These are "dopamine substitutes." They have much
the same effect, subjectively, as increasing the dopamine
concentration, but since they are not converted to norepinephrine,
they do not provide an energy boost (which may be a good thing or not,
depending on your situation). I've had good luck with cabergoline, but
it is relatively expensive if your health insurance doesn't cover it,
in which case one of the others (e.g. bromocriptine, pramipexole)
might be more affordable.
I would recommend that you talk to your psychiatrist about these
medications, and see if something more useful can be done for you. I'd
also suggest that you read up on the medications on my Web site
beforehand.
Good luck to you, and let us know how you are doing.
--
Nom dePlume, Ph.D
Why, yes, in fact, I am a rocket scientist.
Guide to Medications for Mental Illness:
http://www.geocities.com/nomdeplume1000
=====
.


User: "Franz Bestuchev"

Title: Re: Nom de Plume - and thanks to others 23 Mar 2005 06:57:05 PM
He's a rocket scientist
"Allure30" <karine3479@yahoo.ca> wrote in message
news:fdf8dd65.0503230902.2c4cb97c@posting.google.com...

Hi,

First, thank you for answering me pertinent answers :)

Nom de Plume, are you a psychiatrist? psychologist? Where are you
from? Are you ill or a doctor?

Thanks for answering me.

I may look at Depakote, maybe or Anafranil, since I am depressed and
DP unit at London has showed good results with this med. But not SSRI
for me....

I will look at other answers too!

Allure xxx

.


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