Hallucinogen May Cure Drug Addiction
Posted: February 18, 2004 at 8:58 p.m.
BAY AREA (KRON) -- Drug addiction has been the plague of modern
America. But that could now change forever. What started as a rumor
may now actually be an incredible breakthrough in the battle against
addictions of all kinds.
Ibogaine has a number of strikes against it:
It doesn't come from a modern laboratory, but from an ancient plant.
It was discovered not by a scientist, but by a heroin addict.
It is mildly hallucinogenic and completely illegal in the United
States.
However, when it comes to curing addiction, a reputable scientist
believes ibogaine is nothing short of a miracle. "I didn't believe it
when I first heard about ibogaine. I thought it was something that
needed to be debunked," admits Dr. Deborah Mash, professor of
Neurology and Molecular and Cellular Pharmacology at University of
Miami.
Dr. Mash is one of the few scientists in the world to study ibogaine,
a mild hallucinogen that comes from the root of a shrub found in West
Africa and was rumored to have the amazing ability to help drug
addicts kick their addiction.
"This didn't come from the Salk Institute, this didn't come from the
Scripps Institute. This came from a junkie who took a dose to get high
himself. So the original observation came from the underground," says
Dr. Mash.
Observations from this particular underground are not likely to gain
the respect of mainstream society, and ibogaine was no exception.
That first report came in 1962. But decades would pass with little
scientific investigation. There were decades during which the cost of
addiction in terms of medical care, lost productivity, crime and
incarceration rose to $160 billion a year.
The human toll was impossible to calculate.
Patrick Kroupa was a heroin addict for 16 of his 35 years. "It was a
very high level of desperation. I had been pretty successful in my
life, I had accomplished a lot of things I wanted to do, and then
repeatedly I just watched everything burst into flames and
disintegrate because I could not stay off heroin," confesses Patrick.
"It gets very tiring living like a slave because you keep chasing this
and it's like you're not getting high, it's just 'I must do this every
single day just to get normal so I can function.'"
Like most addicts, Patrick tried to quit. But treatment for addiction
is notoriously ineffective. Only one in ten addicts manages to return
to a drug-free life. Most stay dependent on illegal drugs or their
legal substitutes, like methadone.
"And I was a spectacular failure at every possible treatment modality,
every paradigm, every detox, every therapy, nothing ever worked,"
admits Patrick.
Even as Patrick Kroupa despaired of ever kicking heroin, Dr. Mash was
petitioning the Federal Food and Drug Administration to allow a
scientific test of ibogaine, which by this time had been classified as
a "schedule one" drug on a par with heroin. In 1993, the FDA approval
came through.
"We were established, we had a team of research scientists, doctors,
clinicians, psychiatrists, toxicologists and we wanted to go forward
with this," describes Dr. Mash.
But even with FDA approval, Dr. Mash could not get funding to look
into what was, after all, a counter-culture drug. In order to complete
her project, she had to leave South Florida and go offshore, to the
island of St. Kitts.
In 1998, clinical trials finally got underway. Patients were given
carefully prepared oral doses of ibogaine. What happened next
astounded the sceptical scientist.
"Our first round in St. Kitts, we treated six individuals, and I will
go to my grave with the memory of that first round," says Dr. Mash.
It quickly became apparent that one dose of ibogaine blocked the
withdrawal symptoms of even hard-core addicts and was amazingly
effective for heroin, crack cocaine and even alcohol.
There are two reasons why: The first, science can measure. The second
remains a mystery.
Dr. Mash admits, "I was really scared. I questioned my own sanity on
numerous occasions."
"I don't like the word 'hallucinogen,' but indeed, ibogaine alters
mental state. And what it seems to do is it puts people into a four to
six hour state of almost an active dream, it's like a lucid dream."
she describes.
But as Dr. Mash was about to discover, during that dream state,
something extraordinary happens. "We knew ibogaine was effective for
blocking opiate withdrawal, we saw it diminish the desire to use
alcohol. And we saw the cravings for cocaine blocked. I was hooked,"
she says.
Patrick admits, "It's literally like a miracle. Nothing has ever
worked and this just did." He was one of the 280 people in Dr. Mash's
trial of ibogaine.
"Patrick was one of the worst opiate addicts, worst heroin addicts
that I have ever enountered in my life," says Dr. Mash. His arms still
bear the scars of years of heroin addiction, and he knows only too
well what happened when the flow of drugs into those arms was
interrupted. "When you're going through withdrawal, you're sweating,
you're shaking, you're freezing, you're hot, it feels like your spine
is being smashed in a vise, it's pain," describes Patrick.
Within 45 minutes of taking ibogaine, he actually felt his addiction
leaving him. "That moment is the first time in about 10 years that I
had actually been clean. Not just detoxed, but clean. That was it.
That was the first time. That was like a miracle," says Patrick
That was four years ago. Patrick Kroupa has not touched drugs since.
"I'm saying this having been on heroin for my entire adult life. I
mean, 14 to 30 is a long time," he says.
On one level, Dr. Mash understands some of what happens. Ibogaine in
the body is metabolized into another compound called 'noribogaine.'
Noribogaine appears to reset chemical switches in the brain of an
addict.
"The noribogaine resets that, so it resets the opiates, blocks the
opiate withdrawal, diminishes craving and the desire to use, and it
elevates mood," say Dr. Mash.
But of the "visions" that people see, Dr. Mash understands very little
-- only that they are somehow significant to the outcome. "It's as if
the plant is teaching you something fundamental about who you are as a
person and why you've got yourself locked into this intractible
pattern of behavior," she says.
Ibogaine will not work for everyone. And even for those for whom it
does work, it is not a "magic bullet." "You need treatment, you need
social workers, you need case management, you need medication,
psychiatry, you need the whole boat of professionalism around this,"
says Dr. Mash.
But for Patrick Kroupa and many of the other addicts in the trials,
ibogaine was a miracle. "It's like if you suffer from terminal cancer
and somebody goes by and says, 'Oh, yeah, we cured that. We passed
this thing over you and it's gone,'" he says.
Even the reserved scientist believes this ancient drug from Africa
holds astounding promise for the modern world. "I think we're going to
see fantastic numbers. I think these numbers are going to be
stunning," says Dr. Mash.
Dr. Mash will present her findings to the Food and Drug Administration
next month. She hopes the FDA will eventually authorize further
testing, based on her results. In the meantime, ibogaine remains
illegal in the United States.
Ibogaine is advertised on the internet, but there is no guarantee of
the quality unless it's given under medical supervision. And for now,
that can only be done overseas.
For ibogaine detox information, contact Healing Transitions at
1-888-426-4286 or www.Ibogaine.net
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